Tresiba (Insulin Degludec)




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Product Details


Tresiba is a Type 2 diabetes insulin that is a long-acting insulin. It provides extended blood sugar control for patients struggling to get A1C hemoglobin test scores down to the standard 7% acceptable threshold when regulating blood sugar levels. This insulin pen is administered as a subcutaneous injection, and like other long-acting insulins the active ingredient – Degludec - functions throughout the day to help manage your blood sugar between meals and overnight by helping cells absorb more sugar from the bloodstream. Tresiba replaces your natural insulin for up to 42 hours.

Fact Table
Formula C274H411N65O81S6
License FDA approved in 2015
Bioavailability N/A (administered via injection)
Legal status Rx-Only
Chemical Name Insulin Degludec
Elimination half-life 25 hours (can vary)
Dosage (Strength) Available in 100 units/mL and 200 units/mL pens (pre-filled SoloStar 3ml pens)
Pregnancy Consult with healthcare provider
Brands Tresiba
Protein binding Minimal
PubChem CID 56843331
MedlinePlus a613032
ChEBI 85119
ATC code A10AE06
DrugBank DB09564
KEGG D09727
Routes of administration Subcutaneous injection


Standard dosage for Tresiba insulin is to take 1 injection per day.

Injection may be administered into one of 3 acceptable injection sites: thighs, back of upper arms and abdomen (but not within a 2” radius of navel).

Switch to a different injection site for each day’s injection, alternating between the 3 of them at all times to avoid the risk of lipodystrophy.

Take new pen out of fridge approximately 1 hour before planned injection.


  • Wash your hands.
  • Remove the pen cap and make sure the medication is clear and has no color.
  • Clean the rubber seal with an alcohol swab and attach a new pen needle for each injection.
  • Remove the paper tab and push the needle straight onto the pen.
  • Remove the outer pen needle cap and keep it for removing needle following injection.
  • Remove the inner needle cap and discard.


Turn the dose counter to 2 units and press the green injection button in fully until reading ‘0’ (zero) and check for a small amount of solution to come from the needle tip. This will need to be seen before you proceed with administering the injection.


Turn dose counter until correct prescribed dose is loaded and then inject the dose.

At the injection site, insert the needle into your skin at a 90-degree angle then press the green injection button down completely and hold it until ‘0’ shows in dose window.

Count to 6 before releasing the injection button and removing the needle and then release the injection button and remove the needle from your skin.

Remove and discard needle only as shown in your medication.

Store the pen at room temperature after the first use.


The active ingredient in Tresiba is Degludec.


Tell your doctor if you have any history of renal or hepatic impairment, heart failure, low blood potassium levels, edema or other forms of fluid retention before starting on Tresiba.

Medication is not recommended for the treatment of diabetic ketoacidosis.

Keep insulin t refrigerated at between 36°F to 46°F (2°C to 8°C) and at room temperature after first dose has been administered for each Tresiba Flextouch pen.

Be sure to change needles as indicated and do not remove outer cap on pen until you are ready and about to give yourself an injection.


There is the possibility of negative drug interaction risks between Tresiba and other Rx or OTC medications, including:

  • amlodipine
  • aspirin
  • atorvastatin
  • carvedilol
  • furosemide
  • gabapentin
  • empagliflozin
  • levothyroxine
  • lisinopril
  • losartan
  • metformin
  • metoprolol
  • Novolog (insulin aspart)
  • omeprazole
  • semaglutide
  • pantoprazole
  • rosuvastatin
  • dulaglutide
  • cholecalciferol

Tell your doctor of all medications you are currently taking before receiving a medication and proceeding to buy Tresiba insulin online.

Side Effects

Side effects from using Tresiba are possible, and some users may experience diarrhea, headache, itching and rash at injection area, upper respiratory infections, or weight gain. If side effects are seen you may want to discontinue use and speak to your doctor again about insulin pen alternatives to Tresiba as part of Type 2 diabetes treatment.

Frequently Asked Questions about Tresiba

What is Tresiba?

Tresiba is a long-acting insulin for controlling high blood sugar in adults and children as young as 1 year with diabetes.

How is Tresiba pronounced?

Tresiba is pronounced as "Tray-si-bah".

Can children take Tresiba?

Yes, it is approved for children as young as 1 year old, for both type 1 and type 2 diabetes.

How should Tresiba be taken?

It is taken by subcutaneous injection once daily, and the dosage is individualized.

Can Tresiba be used with other diabetes drugs?

Tresiba can be used with diabetes pills or fast-acting insulins, but interactions with some drugs like thiazolidinediones (TZDs) may increase the risk of heart failure.

What are the possible side effects of Tresiba?

Serious side effects can include hypoglycemia, hypokalemia, and heart failure with TZDs. Common side effects include allergic reactions, injection site reactions, and weight gain.

Is Tresiba safe during pregnancy?

Studies have not identified major birth defects or adverse maternal/fetal outcomes with Tresiba use during pregnancy.

How is Tresiba stored and handled?

Unused Tresiba should be refrigerated, but after first use, it can be kept at room temperature or refrigerated for up to 8 weeks.

What is Tresiba FlexTouch?

Tresiba FlexTouch is a prefilled insulin device designed with no push-button extension, suitable for universal fit needles.

What are the insurance and affordability options for Tresiba?

Tresiba is covered by most insurance plans. There are savings cards and assistance programs available for eligible patients.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 13870

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