Tresiba is a Type 2 diabetes insulin that is a long-acting insulin. It provides extended blood sugar control for patients struggling to get A1C hemoglobin test scores down to the standard 7% acceptable threshold when regulating blood sugar levels. This insulin pen is administered as a subcutaneous injection, and like other long-acting insulins the active ingredient – Degludec - functions throughout the day to help manage your blood sugar between meals and overnight by helping cells absorb more sugar from the bloodstream. Tresiba replaces your natural insulin for up to 42 hours.
Fact Table | |
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Formula | C274H411N65O81S6 |
License | FDA approved in 2015 |
Bioavailability | N/A (administered via injection) |
Legal status | Rx-Only |
Chemical Name | Insulin Degludec |
Elimination half-life | 25 hours (can vary) |
Dosage (Strength) | Available in 100 units/mL and 200 units/mL pens (pre-filled SoloStar 3ml pens) |
Pregnancy | Consult with healthcare provider |
Brands | Tresiba |
Protein binding | Minimal |
PubChem CID | 56843331 |
MedlinePlus | a613032 |
ChEBI | 85119 |
ATC code | A10AE06 |
DrugBank | DB09564 |
KEGG | D09727 |
Routes of administration | Subcutaneous injection |
Standard dosage for Tresiba insulin is to take 1 injection per day.
Injection may be administered into one of 3 acceptable injection sites: thighs, back of upper arms and abdomen (but not within a 2” radius of navel).
Switch to a different injection site for each day’s injection, alternating between the 3 of them at all times to avoid the risk of lipodystrophy.
Take new pen out of fridge approximately 1 hour before planned injection.
Turn the dose counter to 2 units and press the green injection button in fully until reading ‘0’ (zero) and check for a small amount of solution to come from the needle tip. This will need to be seen before you proceed with administering the injection.
Turn dose counter until correct prescribed dose is loaded and then inject the dose.
At the injection site, insert the needle into your skin at a 90-degree angle then press the green injection button down completely and hold it until ‘0’ shows in dose window.
Count to 6 before releasing the injection button and removing the needle and then release the injection button and remove the needle from your skin.
Remove and discard needle only as shown in your medication.
Store the pen at room temperature after the first use.
The active ingredient in Tresiba is Degludec.
Tell your doctor if you have any history of renal or hepatic impairment, heart failure, low blood potassium levels, edema or other forms of fluid retention before starting on Tresiba.
Medication is not recommended for the treatment of diabetic ketoacidosis.
Keep insulin t refrigerated at between 36°F to 46°F (2°C to 8°C) and at room temperature after first dose has been administered for each Tresiba Flextouch pen.
Be sure to change needles as indicated and do not remove outer cap on pen until you are ready and about to give yourself an injection.
There is the possibility of negative drug interaction risks between Tresiba and other Rx or OTC medications, including:
Tell your doctor of all medications you are currently taking before receiving a medication and proceeding to buy Tresiba insulin online.
Side effects from using Tresiba are possible, and some users may experience diarrhea, headache, itching and rash at injection area, upper respiratory infections, or weight gain. If side effects are seen you may want to discontinue use and speak to your doctor again about insulin pen alternatives to Tresiba as part of Type 2 diabetes treatment.
What is Tresiba?
Tresiba is a long-acting insulin for controlling high blood sugar in adults and children as young as 1 year with diabetes.
How is Tresiba pronounced?
Tresiba is pronounced as "Tray-si-bah".
Can children take Tresiba?
Yes, it is approved for children as young as 1 year old, for both type 1 and type 2 diabetes.
How should Tresiba be taken?
It is taken by subcutaneous injection once daily, and the dosage is individualized.
Can Tresiba be used with other diabetes drugs?
Tresiba can be used with diabetes pills or fast-acting insulins, but interactions with some drugs like thiazolidinediones (TZDs) may increase the risk of heart failure.
What are the possible side effects of Tresiba?
Serious side effects can include hypoglycemia, hypokalemia, and heart failure with TZDs. Common side effects include allergic reactions, injection site reactions, and weight gain.
Is Tresiba safe during pregnancy?
Studies have not identified major birth defects or adverse maternal/fetal outcomes with Tresiba use during pregnancy.
How is Tresiba stored and handled?
Unused Tresiba should be refrigerated, but after first use, it can be kept at room temperature or refrigerated for up to 8 weeks.
What is Tresiba FlexTouch?
Tresiba FlexTouch is a prefilled insulin device designed with no push-button extension, suitable for universal fit needles.
What are the insurance and affordability options for Tresiba?
Tresiba is covered by most insurance plans. There are savings cards and assistance programs available for eligible patients.