Janumet (Sitagliptin / Metformin)

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Product Details


Janumet is a medicine for treating Type 2 diabetes. It helps in lowering blood sugar. Janumet has two main ingredients. The first ingredients, Sitagliptin, helps your body make more insulin. The second ingredients, Metformin, reduces sugar from food and makes insulin work better. Doctors suggest Janumet for patients already taking Metformin but needing more insulin.

Always talk to your doctor about benefits and side effects before you buy Janumet.

Fact Table
Formula C20H30ClF6N10O5P
License US FDA
Bioavailability 87%
Legal status Rx-Only
Chemical Name Sitagliptin / Metformin
Elimination half-life 8-14 hours
Dosage (Strength) 50mg/500mg, 50mg/850mg, 50mg/1000mg
Pregnancy Consult a doctor
Brands Janumet
Protein binding 38%
PubChem CID 74331896
MedlinePlus a613007
ChEBI 40237
ATC code A10BD07
DrugBank DB01261
KEGG D10261
Routes of administration By mouth (tablets)


Standard dosage is to take Janumet medication 2x daily with meals. Dosage may vary based on doctor’s specifications. You should always take your medication as indicated in your prescription.


The active ingredients in Janumet are Sitagliptin and Metformin.


Tell your doctor if you have any history of:

liver or kidney disease

breathing difficulty conditions like obstructive lung disease or severe asthma,

blood problems like anemia or vitamin B12 deficiency, pancreatitis, or

gallstones before starting on Janumet.

Patients with upcoming x-ray or other scans using iodinated contrast may need to postpone their starting to take Janumet.

Medication use may not be suitable for patients using diuretics (water pills).

Older adults may be more susceptible to Janumet side effects.

Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant.


There is the possibility of negative drug interactions between Janumet and other RX or OTC medications, including

  • hushart
  • ranolazine
  • vandetanib
  • dolutegravir
  • cimetidine
  • metropolol

Tell your doctor of all medications and OTC supplements before receiving a prescription and proceeding to buy Janumet online.

Side Effects

Side effects from using Janumet are possible, and some users may experience:

  • nausea
  • vomiting
  • stomach upset
  • diarrhea
  • headache
  • weakness
  • metallic taste in the mouth

If side effects are experienced you may want to discontinue use and speak to your doctor.

Frequently Asked Questions about Janumet (sitagliptin / metformin)

What is Janumet used for?

Janumet is a prescription medication used to control blood sugar levels in type 2 diabetes. It combines two medicines: sitagliptin, which helps your body release insulin, and metformin, which helps your body use insulin more effectively.

What are the side effects of Janumet?

The most common side effects are mild and include nausea, upset stomach, gas, headache, and stuffy or runny nose. More serious side effects, like lactic acidosis (a buildup of lactic acid in the blood), can occur but are rare.

How often do I take Janumet?

The recommended dosage varies depending on your individual needs and your doctor's instructions. Typically, it's taken once or twice daily with meals.

Can I take Janumet if I have other health conditions?

Not everyone can safely take Janumet. Tell your doctor about all your health conditions, especially kidney or liver problems, heart disease, alcohol use, or if you might be pregnant or breastfeeding.

Can I take Janumet with other medications?

Certain medications can interact with Janumet, so it's crucial to tell your doctor about all the medicines you take, including over-the-counter drugs and supplements.

Will Janumet cause weight loss?

Janumet itself does not cause weight loss, but it can help manage your diabetes, which may indirectly lead to weight loss.

Does Janumet cure diabetes?

No, Janumet does not cure diabetes but helps control blood sugar levels. You'll likely need to continue taking Janumet for as long as you have diabetes.

How long does it take for Janumet to work?

Janumet can start lowering your blood sugar levels within a few days, but it may take several weeks to reach its full effect.

What should I do if I miss a dose of Janumet?

If you miss a dose, take it as soon as possible. However, if it's near your next dose time, skip the missed dose and continue with your regular schedule. Don't take two doses at once.

What should I do if I have side effects from Janumet?

If you experience any side effects, especially serious ones, stop taking Janumet and contact your doctor immediately.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your healthcare professional for medical advice and treatment.

Product Code : 13880

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