Semglee (Insulin Glargine) RX




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Product Details


Semglee is a long-acting insulin medication used for Type 1 and Type 2 diabetes and it is an interchangeable insulin that can be interchanged with Lantus insulin based on a doctor’s recommendation for individual blood control adjustments. It has a comparable duration of action, rate of hypoglycemia, and effects similar to HbA1c plus fasting plasma glucose from baseline. This insulin pen is highly regarded as an interchangeable biosimilar insulin glargine and it works by stimulating peripheral glucose uptake by skeletal muscle and fat and by inhibiting hepatic glucose production.


Injections are to be taken once a day, at the same time each day.

Type 1 diabetes treatment: Semglee is used concomitantly with a short-acting insulin. The recommended starting dose of Semglee insulin in patients with type 1 diabetes should be approximately one-third of the total daily insulin requirements.

Type 2 diabetes treatment: Recommended starting dose of Semglee insulin in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg or up to 10 units once daily.

Remove Semglee pen cap and visually confirm that insulin in pen is clear and not cloudy.

Safety Test

Wipe rubber seal with alcohol / remove protective seal from a new needle.

Line up needle with pen and keep it straight as you screw it on.

Select correct dosage by turning the white knob.

Take off outer cap but keep it to remove used needle after injection / take off inner needle cap and discard it.

Hold the pen with the needle pointing upwards / tap the cartridge so that any air bubbles rise up towards the needle.

Press the purple injection button all the way in and confirm that insulin comes out of the needle tip.


Turn to select dose but be sure to not press purple button while selecting dose.

Insert the needle into skin at proper injection site as indicated in your medication and discussed with your doctor.

Deliver the dose by pushing the purple button in all the way, white dose knob will turn and you will hear click sounds as the Semglee insulin dose is delivered.

Remove and discard needle only as shown in your medication and dispose of responsibly.


The active ingredient in Semglee is Insulin Glargine.


Tell your doctor if you have any history of hypoglycemia, hypokalemia, heart failure, peripheral edema, or fluid retention before starting on Semglee insulin and using a Semglee pen.

Medication is not recommended for the treatment of diabetic ketoacidosis.

Keep insulin stored at the proper temperature as indicated in your medication.

Be sure to change needles as indicated and do not remove outer cap on pen until you are certain you will be giving yourself an injection.


There is the possibility of negative drug interactions between Semglee and other Rx medications, including fluoxetine / pentoxifylline / pramlintide / salicylates / octreotide / sulfonamide antibiotics / DPP-4 inhibitors / SGLT-2 inhibitors / olanzapine / clozapine / corticosteroids / danazol / diuretics, estrogens / glucagon / isoniazid / oral contraceptives / phenothiazines / protease inhibitors / albuterol / epinephrine / terbutaline / clonidine / guanethidine / reserpine.

Tell your doctor of all medications you are taking before receiving a medication and proceeding to buy Semglee insulin from Canada.

Side Effects

Side effects from using Semglee insulin are possible, and some users may experience low blood sugar levels, lightheadedness or dizziness, fatigue, sweating, headache, confusion, speech difficulties, or anxiety or irritability. If Semglee side effects are experienced you may choose to discontinue use and speak to your doctor again about interchangeable insulin alternatives to the Semglee pen.

Frequently Asked Questions about Semglee

What is Semglee?

Semglee is a synthetic insulin used to control blood sugar in patients with diabetes mellitus. It's a long-acting insulin that starts working hours after injection and continues evenly for 24 hours.

Who can use Semglee?

Semglee is suitable for adults with type 1 or 2 diabetes and children at least 6 years old with type 1 diabetes. However, its safety and efficacy in children under 6 and those with type 2 diabetes are not established.

How should Semglee be used?

Semglee is injected under the skin, usually once daily at the same time. It should not be used with an insulin pump or mixed with other insulins.

What are the contraindications for using Semglee?

Avoid Semglee during episodes of low blood sugar (hypoglycemia) or if allergic to insulin glargine or any of its ingredients. It's also not recommended for treating diabetic ketoacidosis.

Are there any necessary precautions while using Semglee?

Tell your doctor if you have liver or kidney problems, heart issues, or if you're pregnant or breastfeeding. Also, inform them about any other medications you're taking.

What should be avoided while using Semglee?

Avoid driving or operating heavy machinery until you know how Semglee affects you. Alcohol consumption and use of medicines containing alcohol should also be avoided.

How is Semglee stored?

Unopened Semglee should be refrigerated or stored at room temperature, used by the expiration date or within 28 days. Opened vials or pens should also be used within 28 days.

What should I do if I miss a dose or overdose?

If you miss a dose, call your doctor for instructions. Do not double doses. In case of overdose, seek emergency medical attention, as it can lead to severe hypoglycemia.

What are potential side effects of Semglee?

Common side effects include low blood sugar, swelling, weight gain, and skin reactions at the injection site. Severe side effects may include allergic reactions and low potassium levels.

How does Semglee interact with other drugs?

Many drugs can affect blood sugar levels and interact with Semglee. Inform healthcare providers about all medications, including over-the-counter and herbal products you use.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 13873

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