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ProZinc is a long-acting insulin derived from recombinant human insulin, combined with zinc and protamine to prolong its release into the body. It's specifically formulated to control blood glucose levels in pets with diabetes mellitus. ProZinc works by stimulating carbohydrate metabolism in heart, bone, and fat tissue, aiding these cells in using glucose for energy. It's the first and only FDA-approved insulin for cats made from recombinant DNA technology, and it's now also approved for use in dogs.
Before you buy Prozinc insulin, it is important that you talk to your healthcare provider about its effectiveness and potential side effects.
| Fact Table | |
|---|---|
| Formula | C257H383N65O77S6 (for human insulin) |
| License | FDA approved |
| Bioavailability | Not typically applicable |
| Legal status | OTC |
| Chemical Name | Insulin human (rDNA origin) Zinc salt, Protamine sulfate complex |
| Elimination half-life | 7-13 hours |
| Dosage (Strength) | Available as U-40 insulin (40 units of insulin per milliliter) |
| Pregnancy | Consult healthcare provider |
| Brands | PROZINC |
| Protein binding | Insulin has a low extent of protein binding |
| PubChem CID | 16132418 |
| MedlinePlus | Not applicable (veterinary medicine) |
| ChEBI | 6804 |
| ATC code | A10AB01 |
| DrugBank | DB00030 |
| KEGG | D00040 |
| Routes of administration | Subcutaneous injection |
ProZinc should be administered as directed by a veterinarian and is given using a U-40 syringe only. The vial should be mixed by rolling between the palms before use without shaking. It's important to use the correct type of syringe to ensure accurate dosing. Dosage regimens vary, with the recommended starting dose for cats being 0.1 to 0.3 units per pound of body weight every 12 hours, and for dogs, 0.2 to 0.5 units per pound of body weight once daily. Dosage may need adjustment based on changes in the pet's diet, body weight, or other medications.
Each ml of ProZinc contains 40 International Units (U) of recombinant human insulin. The product is a sterile injectable suspension in 10 ml multidose vials.
ProZinc is for use in dogs and cats only and should be kept out of reach of children. It's contraindicated in animals sensitive to protamine zinc recombinant human insulin or other ingredients in the product, and during episodes of hypoglycemia. Accidental injection in humans may cause hypoglycemia and requires immediate medical attention. Any change in insulin should be made cautiously and only under a veterinarian's supervision. Owners should be aware of the signs of hypoglycemia and treat them immediately if they occur.
Glucocorticoids, progestogens, and certain endocrinopathies can antagonize insulin activity. Use of glucocorticoid and progestogen should be avoided in pets being treated with ProZinc. Adjustments in dosage may be necessary if the pet is on concomitant medication or develops concurrent medical conditions like infection, inflammation, neoplasia, or additional endocrine disorders.
Side effects observed in studies include hypoglycemia, injection site reactions, diabetic neuropathy, and diabetic ketoacidosis. Hypoglycemia may manifest as lethargy, weakness, trembling, uncoordination, or seizures, and should be treated immediately. Injection site reactions and diabetic neuropathy (plantigrade stance) were also reported. In some cases, euthanasia was chosen due to poor response to treatment or worsening concurrent medical conditions.
ProZinc requires refrigeration and must be kept at refrigerator temperatures at all times. It's important to follow any diet or exercise plan developed by your veterinarian and to regularly monitor the pet for any changes in condition or response to treatment.
What is ProZinc?
ProZinc is an FDA-approved veterinary insulin made with recombinant technology, specifically formulated with protamine zinc to support optimal glycemic control and extended duration of action in cats and dogs.
What animals is ProZinc designed for?
ProZinc is exclusively for use in dogs and cats to control diabetes mellitus.
How effective is ProZinc in controlling diabetes in animals?
In clinical studies, ProZinc showed significant improvement in controlling excessive thirst and urination in both canine and feline patients. About 72% of dogs and approximately half of cats showed improvement in diabetic control.
Is ProZinc convenient for pet owners?
Yes, ProZinc allows for once-a-day administration in dogs, offering convenience for dog owners and potentially improving the quality of life for diabetic dogs.
Are there any safety concerns with ProZinc?
Owners should observe their pets for signs of hypoglycemia (low blood sugar), which can include weakness, depression, behavioral changes, muscle twitching, and anxiety. Severe hypoglycemia can lead to seizures, coma, and can be fatal if not treated promptly. ProZinc should not be used during episodes of hypoglycemia.
Can ProZinc be used in puppies and kittens?
The safety and effectiveness of ProZinc in puppies, kittens, or breeding, pregnant, and lactating animals have not been evaluated.
