Orilissa (Elagolix)

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Product Details


Orilissa (Elagolix) is a medicine given to women to help ease the pain from a condition known as endometriosis. Endometriosis happens when tissue similar to the lining of the womb grows in other places, like on the ovaries or other organs. It can lead to symptoms like painful periods, pain during or after sex, and problems getting pregnant.

Elagolix works by lowering the production of certain hormones, which reduces estrogen levels in the body. This can help relieve some symptoms of endometriosis.


Take this medication orally as directed by your doctor, with or without food.

Take the medication regularly at the same time, usually once or twice daily.

How much and how long you need to take this medicine depends on your health, how you react to the treatment, and any other medicines you're taking.

Before you start taking this medicine, your doctor might do a pregnancy test or tell you to start it within 7 days after your period begins. This is to make sure you're not pregnant.

Typically, this medication is taken for up to 6 months or up to 24 months to minimize the risk of bone loss.


The active ingredient in Orilissa is Elagolix Sodium.


Inform your doctor if you have allergies to Elagolix or any other substances.

Before you start this medicine, make sure to tell your doctor about all your past health issues, especially if you've had:

  • liver problems,
  • bone loss, or
  • mood issues like depression

Do not use this medication during pregnancy, as it may harm an unborn baby.

Consult your doctor before breastfeeding.


Orilissa (elagolix) can interact with 349 different drugs. This includes major interactions with drugs like:

  • Adderall
  • Benadryl
  • ibuprofen

and moderate interactions with drugs like

  • cetirizine
  • metformin
  • sertraline

For a full list of these interactions, you can check the Orilissa prescribing information.

Side Effects

The typical Orilissa side effects include:

  • Fluctuations in body temperature characterized by sudden heat sensations
  • Perspiration experienced during nighttime
  • Absence or irregularity of menstrual cycles
  • Alterations in emotional state
  • Aching or discomfort in the joints
  • Feeling of sickness or queasiness
  • Headache
  • Difficulty falling asleep or staying asleep.

There may be other potential adverse reactions associated with Orilissa. Before you buy Orilissa, make sure you talk to your doctor for medical advice about these side effects.

Frequently Asked Questions about Orilissa

What is Orilissa?

Orilissa, a medication for treating moderate to severe pain caused by endometriosis, works by lowering estradiol and progesterone levels.

Can Orilissa be used during pregnancy?

Orilissa should not be used during pregnancy, as it may cause miscarriage.

How does Orilissa affect birth control methods?

Hormonal birth control methods may be less effective with Orilissa. Non-hormonal methods like condoms are recommended during treatment and for one week after.

What are the contraindications for using Orilissa?

Do not use Orilissa if you are allergic to elagolix, have osteoporosis, severe liver disease, or are taking certain medications like cyclosporine, gemfibrozil, or rifampin.

Can Orilissa affect menstrual periods?

Orilissa may alter menstrual periods, making it harder to recognize pregnancy. Signs like breast tenderness, nausea, and weight gain can indicate pregnancy.

Is Orilissa safe for breastfeeding?

The safety of Orilissa during breastfeeding hasn't been adequately studied. Weigh potential benefits against risks before use.

How should Orilissa be taken?

Orilissa should be taken as prescribed, at the same time each day, with or without food. It's crucial to follow your doctor's dosing instructions carefully.

What are the dosage guidelines for Orilissa?

The usual adult dose for endometriosis pain management is 150 mg once a day for 24 months. For dyspareunia, consider 200 mg twice a day for 6 months.

What are the side effects of Orilissa?

Common side effects include hot flushes, headaches, nausea, insomnia, mood changes, menstrual period changes, and joint pain. Serious side effects like allergic reactions, liver problems, depression, and suicidal thoughts need immediate medical attention.

How should Orilissa be stored?

Store Orilissa at room temperature, away from heat and moisture, and keep it out of children's reach. Dispose of unused medicine through a take-back program or as directed in the MedGuide.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 13919

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