Novolin R (Insulin)

Also known as Novolin GE Toronto (in Canada)




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Product Details


Novolin R is a short-acting insulin that begins to lower blood sugar within 30-60 minutes of administration. It reaches its peak effectiveness within 2 to 3 hours and continues to level blood glucose for 7-8 hours. Novolin R can be used in the treatment of both Type 1 and Type 2 diabetes. As a short-acting insulin, it provides immediate blood glucose leveling, addressing the primary concern of blood sugar spikes after meals. Insulin regular facilitates the movement of blood sugar into cells for energy use, rather than allowing it to remain in the blood. Taking Novolin R also means that a patient’s blood sugar will peak earlier after meals and will be much less elevated in the subsequent hours.

Before you buy Novolin R Insulin, it is important that you talk to your healthcare provider about its effectiveness and potential side effects.

Fact Table
Formula C257H383N65O77S6
License FDA approved
Bioavailability Approximately 70% (subcutaneous)
Legal status Rx-Only
Chemical Name Regular Insulin human
Elimination half-life 1-1.5 hours (subcutaneous)
Dosage (Strength) 100 units/ml 10 ml (Vial), 100 units/ml 3ml(pens)
Pregnancy Generally considered safe
Brands Novolin R
Protein binding None
PubChem CID 16132418
MedlinePlus a682611
ChEBI 16169
ATC code A10AB01
DrugBank DB00030
KEGG D04475
Routes of administration Subcutaneous injection


Standard dosage guidelines for Novolin R is to administer injection 30 minutes before each meal of the day. A Novolin R sliding scale may be advised by your doctor to determine what is the best dose for you.

Injection may be made into one of 4 acceptable injection sites: buttocks / thighs / abdomen (excluding a 2” radius around navel) / back of upper arm.

Choose a different injection site for every new injection. Successive injections at the same injection site may promote lipodystrophy of skin at injection site.


Wash your hands.

Prepare syringe for injection, including attaching needle if required depending on the type of syringe you are using.


Insert needle tip through vial covering and into Novolin R insulin solution and pull back on plunger handle to fill syringe with insulin, measuring correct amount by looking at measurement points on the syringe.

Once syringe is filled to the correct amount, remove the needle from the vial and keep needle in upright position and firmly in hand as you prepare to administer the injection.

Administer Novolin R injection in one of the three spots listed above.

Allow needle to remain in your skin for at least 5 seconds to ensure all of your insulin dose has been injected.


The active ingredients in Novolin R is Insulin Regular Human.


Tell your doctor if you have any history of heart failure, kidney or liver problems, low blood sugar (hypoglycemia), low potassium levels (hypokalemia), or allergic reactions before starting on Novolin R insulin.

Medication is not suitable for the treatment of diabetic ketoacidosis.

Keep Novolin R insulin stored at 36°F to 46°F (2°C to 8°C) or at room temperature below 86°F (30°C) as indicated in your medication. Keep opened Novolin R vials stored at a temperature less than 77°F (25°C), but any unused vials must be thrown out after 42 days.


There is the possibility of negative drug interactions between Novolin R and other Rx or OTC mediations, including:

  • Oral antidiabetic medications
  • Pramlintide acetate
  • Angiotensin converting enzyme (ACE) inhibitors
  • Disopyramide
  • Fibrates
  • Fluoxetine (Prozac)
  • Monoamine oxidase (MAO) inhibitors
  • Propoxyphene
  • Salicylates
  • Somatostatin analogs like octreotide
  • Sulfonamide antibiotics
  • Corticosteroids
  • Niacin
  • Danazol
  • Diuretics
  • Isoniazid
  • Somatropin
  • Atypical antipsychotics
  • Clonidine
  • Pentamidine

Tell your doctor of all medications you are taking before receiving a medication and proceeding to buy Novolin R insulin from Canada.

Side Effects

Novolin R side effects are possible, and some users may have sweating, shakiness, dizziness or lightheadedness, elevated heartbeat, blurred vision, feet or hand tingling, slurred speech, anxiety, irritability or mood change, concentration difficulties, or headache. If these side effects are experienced you may want to stop use and meet with your doctor again to discuss insulin vial alternatives to Novolin R for Type 1 and Type 2 diabetes treatment.

Frequently Asked Questions about Novolin R

What is Novolin R?

Novolin R is a short-acting insulin used to control high blood sugar in people with diabetes. It helps glucose get into cells to provide them with energy.

How is Novolin R used?

It is typically injected subcutaneously (under the skin) about 30 minutes before a meal. The dosage is determined by your doctor based on your medical condition and response to treatment.

Who should not use Novolin R?

Individuals with hypoglycemia (low blood sugar) or hypersensitivity to Novolin R or any of its components should not use it. It's important to discuss your medical history with your healthcare provider before starting Novolin R.

What are the potential side effects of Novolin R?

Common side effects include hypoglycemia, allergic reactions at the injection site, weight gain, and swelling. Severe hypoglycemia can be life-threatening. Always monitor your blood sugar levels regularly.

How should Novolin R be stored?

Unopened vials should be stored in the refrigerator, while opened vials may be kept at room temperature but must be used within a certain number of days. Avoid exposing it to extreme heat or light.

Can Novolin R be mixed with other insulins?

Novolin R can sometimes be mixed with intermediate-acting insulin but should never be mixed with insulin glargine. Always follow your doctor's instructions regarding insulin mixing.

What should I do if I miss a dose of Novolin R?

If you miss a dose, take it as soon as you remember unless it's close to the time for your next dose. Never double up doses. Consult your healthcare provider for specific advice.

How does Novolin R interact with other medications?

Certain medications can affect how Novolin R works, potentially causing hypoglycemia or hyperglycemia. Inform your doctor about all medications you're taking, including over-the-counter drugs and supplements.

Can pregnant or breastfeeding women use Novolin R?

Novolin R may be used during pregnancy or while breastfeeding, but it's important to discuss with your healthcare provider as insulin needs may change during these periods.

What should I do in case of an overdose?

An overdose of Novolin R can lead to severe hypoglycemia. Symptoms may include confusion, extreme weakness, blurred vision, or unconsciousness. Seek immediate medical attention in the event of an overdose.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your healthcare professional for medical advice and treatment.

Product Code : 13879

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