Novolin N (Insulin)

Also known as Novolin GE NPH (in Canada)




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Product Details


Novolin N is a intermediate-acting insulin and a recombinant insulin that functions as an exact copy of the insulin produced naturally by the human body. Novolin N can be used for treatment of both Type 1 and Type 2 diabetes, and as an intermediate-acting insulin it provides more gradual and extended blood glucose control for patients who don’t have high blood sugar spikes as much as having their levels stay elevated longer term after eating. Insulin human works by moving glucose out of the bloodstream and into cells to lower the blood sugar levels, and dose titration and sliding scale dosing are quite common with this insulin.

Before you buy Novolin N Insulin, it is important that you talk to your healthcare provider about its effectiveness and potential side effects.

Fact Table
Formula C256H381N65O79S6
License FDA approved
Bioavailability Not applicable (administered via injection)
Legal status Rx-Only
Chemical Name Insulin human (rDNA origin) isophane
Elimination half-life 4-12 hours
Dosage (Strength) 100 units/ml 10 ml (Vial), 100 units/ml 3ml(pens)
Pregnancy Generally considered safe
Brands Novolin N
Protein binding Minimal
PubChem CID 16132418
MedlinePlus a601148
ChEBI 6801
ATC code A10AC01
DrugBank DB00030
KEGG D04475
Routes of administration Subcutaneous injection


Standard dosage guidelines for Novolin N is to administer injection 30 minutes before each meal of the day.

Injection may be administered into one of 4 acceptable injection sites: abdomen (excluding a 2” radius around navel) / back of upper arm / buttocks / thighs.

Choose a different injection site for every new injection. Injection at the same injection site consecutively increases the risk of lipodystrophy.


Wash your hands.

Prepare syringe for injection, including attaching needle if required depending on the type of syringe you are using.


Insert needle tip through vial covering and into Novolin NPH insulin solution and pull back on plunger handle to fill syringe with insulin, measuring correct amount by looking at measurement points on the syringe.

Once syringe is filled to the correct amount, remove the needle from the vial and keep needle in upright position and firmly in hand as you prepare to administer the injection.

Administer Novolin NPH injection in one the three spots listed above.

The needle should stay in your skin for at least 5 seconds to make sure you have injected all of your insulin dose.


The active ingredient in Novolin N is insulin isophane, also known as NPH (Neutral Protamine Hagedorn) insulin.


Tell your doctor if you have any history of heart failure, kidney or liver problems, low blood sugar (hypoglycemia), low potassium levels (hypokalemia), or allergic reactions before starting on Novolin N insulin.

Medication is not recommended for the treatment of diabetic ketoacidosis.

Keep Novolin N insulin stored at 36°F to 46°F (2°C to 8°C) or at room temperature below 86°F (30°C) as indicated in your medication. Keep opened Novolin N vials stored at a temperature less than 77°F (25°C), but any unused vials must be discarded after 42 days.


There is the possibility of negative drug interactions between Novolin N and other Rx medications, including:

  • Glyburide
  • Glimepiride
  • Lisinopril
  • Enalapril
  • Benazepril
  • Irbesartan
  • Olmesartan
  • Losartan
  • Valsartan
  • Gemfibrozil
  • Fenofibrate
  • Fluoxetine (Prozac)
  • Phenelzine
  • Tranylcypromine
  • Selegiline
  • Disopyramide
  • Pentoxifylline
  • Octreotide
  • Olanzapine
  • Clozapine

Tell your doctor of all medications you are taking before receiving a medication and proceeding to buy Novolin N insulin from Canada.

Side Effects

Novolin N side effects are possible, and some users may have injection site skin irritation, lipodystrophy, weight gain, headache, or edema (swelling in feet and / or ankles). If these side effects are experienced you may want to discontinue use and speak to your doctor again about insulin vial alternatives to Novolin N for Type 1 and Type 2 diabetes treatment.

Frequently Asked Questions about Novolin N

What is Novolin N?

Novolin N is an intermediate-acting insulin used to lower blood sugar levels in patients with diabetes. It starts working within 2 to 4 hours after injection, peaks in 4 to 12 hours, and keeps working for 12 to 18 hours.

What is Novolin N used for?

It is indicated for the treatment of both Type 1 and Type 2 diabetes to improve blood sugar control in adults and children.

How should Novolin N be used?

Novolin N should be injected under the skin as directed by a healthcare provider. It should not be mixed with other insulins, injected into a vein or muscle, and should not be used in an insulin pump. The injection site should be rotated to avoid injecting into the same place consecutively.

What are the side effects of Novolin N?

Common side effects include low blood sugar, weight gain, skin reactions at the injection site, and fluid retention. Serious side effects can include allergic reactions, low potassium levels, irregular heartbeats, and difficulty breathing.

What should I tell my doctor before taking Novolin N?

Inform your doctor about any allergies to Novolin N or its ingredients, any other drugs or substances you are allergic to, and all other medications, vitamins, and health problems you have.

What should I do if I miss a dose of Novolin N?

If you miss a dose, use the medicine as soon as possible. However, if it's almost time for your next dose, skip the missed dose and return to your regular schedule. Do not use two doses at one time.

How should Novolin N be stored?

Store unopened containers in a refrigerator, and do not freeze them. Once opened, know how long the product is good for and how to store it, and protect it from heat and light.

What precautions should be taken while using Novolin N?

Inform all healthcare providers that you use Novolin N. Avoid tasks requiring alertness until you know how it affects you. Be cautious with alcohol consumption as it can cause low blood sugar and may interfere with diabetes treatment.

Can Novolin N be used in combination with other diabetes medications?

Novolin N may interact with other diabetes medications, so it's essential to consult with a healthcare provider to ensure safe and effective use. Some diabetes drugs may increase the risk of heart failure when used with insulin.

Are there any special considerations for using Novolin N in certain populations?

Extra care should be taken when using Novolin N in older adults (65 years and above) as they may have more side effects. Additionally, discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding to understand the benefits and risks.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your healthcare professional for medical advice and treatment.

Product Code : 13878

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