Prescription Required
Janumet XR is a medicine used to lower blood sugar levels. It works longer than the regular Janumet. This medicine has two main ingredients. Sitagliptin helps the body make more insulin. Metformin Hydrochloride reduces sugar from food and helps insulin work better. Janumet XR is good for people who need extra insulin and the long-lasting effects of Metformin.
| Fact Table | |
|---|---|
| Formula | C20H30ClF6N10O5P |
| License | US FDA |
| Bioavailability | 87% |
| Legal status | Rx-Only |
| Chemical Name | Sitagliptin / Metformin |
| Elimination half-life | 8-14 hours |
| Dosage (Strength) | 50mg/500mg, 50mg/1000mg, 100mg/1000mg |
| Pregnancy | Consult a doctor |
| Brands | Janumet XR |
| Protein binding | 38% |
| PubChem CID | 74331896 |
| MedlinePlus | a613007 |
| ChEBI | 40237 |
| ATC code | A10BD07 |
| DrugBank | DB01261 |
| KEGG | D10261 |
| Routes of administration | By mouth (tablets) |
Usually, you take Janumet XR once a day with a meal. The exact amount you take can change depending on what your doctor says. Always take your medicine the way your prescription tells you to.
The active ingredients in Janumet XR are Sitagliptin and Metformin Hydrochloride.
Tell your doctor if you have any history of:
Patients with upcoming x-ray or other scans using iodinated contrast may need to postpone their starting to take Janumet XR.
Medication use may not be appropriate for patients using diuretics (water pills).
Janumet XR side effects may be more pronounced in older adults.
Metformin Hydrochloride may affect your menstrual cycle and make it more likely for you to get pregnant.
There is the possibility of negative drug interactions between Janumet XR and other RX or OTC medications, including:
Tell your doctor of all medications and OTC supplements before receiving a prescription and proceeding to buy Janumet XR online.
Side effects from using Janumet XR are possible, and some users may experience:
If side effects are experienced you may want to discontinue use and speak to your doctor.
What is Janumet XR?
Janumet XR is a prescription medicine combining sitagliptin and metformin, used alongside diet and exercise to lower blood sugar in adults with type 2 diabetes. It is not for type 1 diabetes or people with a history of pancreatitis.
How does Janumet XR work?
It targets three key factors: increasing insulin production by the pancreas, improving insulin effectiveness, and reducing sugar production by the liver.
What are the possible side effects of Janumet XR?
Serious side effects include lactic acidosis, a rare but potentially fatal condition.
Will I gain weight from taking Janumet XR?
Janumet XR alone is not likely to cause weight gain.
Difference in taking Janumet and Janumet XR?
Janumet is taken twice daily, whereas Janumet XR is taken once daily.
Does Janumet XR cause low blood sugar (hypoglycemia)?
Alone, it's unlikely to cause hypoglycemia but the risk is higher if taken with certain other medicines.
Can I take Janumet XR if Iām already taking metformin?
Yes, adding sitagliptin to metformin can further lower blood sugar levels.
How should I take Janumet XR?
Follow your doctor's instructions, take with meals to avoid stomach upset, do not break or cut the tablets, and adjust the dose as recommended in specific conditions like dehydration or surgery.
Common side effects of Janumet XR?
They include stuffy or runny nose, sore throat, gas, upset stomach, indigestion, headache, upper respiratory tract infection, weakness, diarrhea, hypoglycemia when used with certain medicines, nausea, and vomiting.
What should I do in case of an overdose?
If you take too much Janumet XR, immediately contact your doctor or local Poison Control Center.
