Humalog 75/25 (Insulin Lispro)

Also known as Humalog Mix25 (in Canada)




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Product Details


Humalog is a combination insulin that is an intermediate-dominant / rapid-acting insulin and better for people who need more blood sugar control between meals rather than immediate lowering of blood sugar levels that spike after meals. Insulin lispro is absorbed more quickly to control blood sugar during meals while the intermediate-acting lispro protamine insulin lasts longer in the body to control blood sugar between eating times. The 75% protamine insulin in this Humalog 75 25 mix means it is more of an intermediate acting insulin but still has some of the function of a fast-acting insulin.


Standard dosage guidelines for Humalog are to administer injection 15 minutes before a meal or immediately after a meal.

Humalog 75/25 is typically dosed twice daily and each dose intended to cover 2 meals / meal and snack. Doctor may modify your dosage guidelines and you should always use this medication exactly as indicated in your medication.

Injection may be made into one of 3 acceptable injection sites: thighs / abdomen (outside a 2” radius around navel) / back of upper arms.

Be sure to use a different injection site for every new injection, as injecting at the same site repeatedly may result in harm to skin (lipodystrophy) at injection the site.


Wash your hands.

Remove the cap and look to confirm the medication is clear and has no color.

Prepare syringe for injection, including attaching needle if required depending on the type of syringe you are using.


Insert needle tip through vial covering and into Humalog 75/25 insulin vial and pull back on plunger handle to fill syringe with insulin and identifying correct amount via measurement points on the syringe.

Once syringe is filled to the correct amount, remove the needle from the vial and keep needle in upright position and firmly in hand as you prepare to administer the injection.

Give yourself the insulin injection in one of the three spots listed above.


The active ingredients in Humalog 75/25 are Insulin Protamine and Insulin Lispro.


Tell your doctor if you have any history of heart failure, kidney or liver problems, low blood sugar (hypoglycemia), low potassium levels, or allergic reactions before starting on Humalog 75/25 insulin.

Medication is not recommended for the treatment of diabetic ketoacidosis.

Keep Humalog 75/25 insulin stored at 36°F to 46°F (2°C to 8°C) or at room temperature below 86°F (30°C) as indicated in your medication


There is the possibility of negative drug interactions between Humalog and other Rx medications, including glyburide / glimepiride / lisinopril / enalapril / benazepril / irbesartan / olmesartan / losartan / valsartan / gemfibrozil / fenofibrate / fluoxetine (Prozac) / phenelzine / tranylcypromine / selegiline / disopyramide / pentoxifylline / octreotide / olanzapine / clozapine.

Tell your doctor of all medications you are taking before receiving a medication and proceeding to buy Humalog 75/25 insulin from Canada.

Side Effects

Humalog insulin side effects may occur, and some users may experience injection site skin irritation, lipodystrophy, weight gain, headache, or edema (swelling in ankles and / or feet). If side effects are experienced you may want to discontinue use and speak to your doctor again about insulin vial alternatives to Humalog 75/25 for Type 1 and Type 2 diabetes treatment.

Frequently Asked Questions about Humalog 75/25

What is Humalog 75/25?

Humalog 75/25 is a combination of fast-acting and intermediate-acting insulins used to control blood sugar levels in people with diabetes.

How is it administered?

It's administered as an injection under the skin, in areas such as the stomach, buttocks, thigh, or upper arm. Proper rotation of injection sites is important to prevent skin problems.

What are the dosage guidelines?

Dosage is individualized and determined by a doctor, based on the patient's blood sugar levels. It's crucial not to alter the dose without consulting a healthcare professional.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the doses.

How should this medication be stored?

Store unopened vials or pens in the refrigerator and avoid freezing. Opened pens can be stored at room temperature for up to 10 days, while opened vials can be stored in the refrigerator or at room temperature for up to 28 days.

What precautions should I be aware of?

Regular doctor visits for blood tests are important to monitor for side effects. It's crucial never to share insulin pens or needles due to the risk of transmitting infections. Be cautious about alcohol consumption, as it can cause low blood sugar.

What are the signs of low blood sugar, and how should it be treated?

Symptoms include anxiety, blurred vision, confusion, dizziness, excessive hunger, and fast heartbeat. Treat low blood sugar immediately with glucose tablets, corn syrup, or fruit juice, and seek medical attention if symptoms don't improve.

What are the symptoms of high blood sugar?

Symptoms include blurred vision, drowsiness, dry mouth, increased urination, and unusual thirst. High blood sugar may occur if you don't take enough insulin or skip doses.

Are there any potential side effects?

Side effects can include low blood sugar, allergic reactions like rash or difficulty breathing, and local reactions at the injection site such as pain or irritation. Some side effects may require medical attention.

Can Humalog 75/25 affect my ability to drive or operate machinery?

This medication may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 13895

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