Aklief Cream (Trifarotene)

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Product Details


Aklief cream is a prescription acne treatment cream used for acne vulgaris treatment. It is a retinoid medication with an active ingredient – Trifarotene – that works by targeting retinoic acid RAR gamma receptors so that sebaceous glands produce less sebum and pores are less clogged as a result. It also promotes blemished healing more quickly and another part of the appeal for Aklief 0.005 topical cream is that it is equally effective for truncal acne treatment when acne is on the chest, shoulders, and back. Buy Aklief cream from Diabetic Online and get the lowest Aklief cream price.

Fact Table
Formula C29H33NO4
License FDA approved
Bioavailability 44%
Legal status Rx-Only
Chemical Name Trifarotene
Elimination half-life 2 to 9 hours
Dosage (Strength) 0.005 % (75 grams)
Pregnancy Consult your Healthcare Provider
Brands Aklief Cream
Protein binding 99.9%
PubChem CID 11518241
MedlinePlus a620004
ChEBI Unknown
ATC code D10AD06
DrugBank DB12808
KEGG D11225
Routes of administration Topical


Gently cleanse and dry affected skin areas. Make sure skin is entirely dry before application.

Apply a thin layer of Aklief 0.00 topical cream 1x each day in the evening.

Use a larger amount if acne covers back areas.

Wash hands with soap and water after application.


The active ingredient in Aklief Cream is Trifarotene.


For use with ages 12 and up.

Tell your doctor of any history of eczema, seborrheic dermatitis, or skin allergies before starting on Aklief cream.

For topical use on skin only. Keep topical acne cream away from mouth, nose, eyes, and ears.

Medication use can increase sun sensitivity for skin. Cover, use shade or sun protection if going to have prolonged exposure to direct sun on treated skin.

Medication may cause skin dryness or irritation.

Women who are pregnant or breastfeeding should only use Aklief cream if their doctor approves it.


Negative drug interactions between Aklief Cream and other Rx medications are a possibility, including aminolevulinic acid / benzoyl peroxide topical / clascoterone topical / isotretinoin / methoxsalen / methyl aminolevulinate topical / porfimer / resorcinol topical / salicylic acid topical / sulfur topical/ verteporfin.

Inform your doctor of all medications you are currently taking before receiving a prescription and proceeding to buy Aklief cream online.

Side Effects

Aklief side effects can occur, and some users may have itching or redness at the application site, or in rare cases may have pain or skin rash. If side effects are seen, you may want to stop use and talk to your doctor again regarding medicated acne cream treatment alternatives.

Frequently Asked Questions about Aklief Cream (Trifarotene)

What is Aklief Cream?

Aklief Cream is a prescription acne treatment containing trifarotene, a fourth-generation retinoid. It's FDA-approved for treating acne vulgaris on the face, shoulders, chest, and back.

How does Aklief Cream work?

Trifarotene, the active ingredient, targets the retinoic acid receptor gamma, reducing inflammation and other factors that cause acne. It's effective in controlling skin cell growth and differentiation, improving skin texture, and encouraging cell turnover.

What are the benefits of using Aklief Cream?

It treats both facial and truncal acne (acne on the chest and back), maintains effectiveness over time, improves skin hydration, and boosts cell turnover. It has shown significant improvement in acne in as early as 12 weeks.

Who can use Aklief Cream?

It's indicated for the topical treatment of acne vulgaris in patients aged 9 years and older.

Does Aklief Cream treat blackheads and whiteheads?

Yes, it may help reduce inflammatory acne, blackheads, and whiteheads.

Are there any side effects or risks associated with Aklief Cream?

Common side effects include sunburn, application site itchiness, and skin irritation. Photosensitivity is a notable risk, so using sunscreen and protective clothing is important. It's not studied in breastfeeding individuals and not recommended during pregnancy.

How should Aklief Cream be applied?

It should be applied once a day in the evening to clean, dry skin. Apply a thin layer as directed by your healthcare provider, using 1 pump for the face and 2 pumps for the upper back, shoulders, and chest.

Can Aklief Cream be combined with other treatments?

It should not be used with other retinoids, keratolytic agents, or astringents to avoid excessive irritation. Also, avoid applying it to cuts, eczematous skin, or sunburned areas, and don't use waxing as a hair removal method on treated skin.

How long does it take to see results from Aklief Cream?

Clinical trials have shown significant reduction in facial acne lesions as early as 2 weeks, but individual results may vary.

What precautions should be taken while using Aklief Cream?

Avoid exposure to sunlight and use sun protection. Keep the cream away from eyes, lips, mouth, corners of the nose, and genital areas. Store it at room temperature and out of reach of children.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 13704

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